BACKGROUND:The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers.Mechanisms regulating INK4/ARF expression are not fully characterized.PRINCIPAL FINDINGS:Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Co
Advances in sequencing technologies and bioinformatics have greatly enhanced our knowledge of virus biodiversity.Currently, the viromes of hematophagous invertebrates, such as mosquitoes and ixodid ticks, are being actively studied.Tabanidae (Diptera) are a widespread family, with members mostly known for their persistent hematophagous behavior.The
Background: Child abuse is a serious public health issue in low- and middle-income countries, and children with disabilities are at greater risk of abuse.Despite this heightened risk, the abuse of children with disabilities often goes undetected and under-reported, leading to the continuity of such abuse by Double Oven Range their abusers.Objective